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This family incorporates only one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was found to methylate, apart from histone, numerous non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and elements of the TATA binding protein (TBP) advanced, TBP-associated components TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-Okay (target lysine is bold), can also be recognized by the H3K4 demethylase KDM1A/LSD1, solicitor uk which is capable of removing the methyl mark on most of those substrates 17 , 94 Subsequently KMT7/KDM1A has emerged as a traditional model for dynamic lysine methylation of each histone and non-histone proteins.

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The members of the SUV39 family mentioned above are involved in both euchromatin and heterochromatin, however another member of the same household, G9a, is the predominant histone H3 K9 methyltransferase in mammalian euchromatin 14 There are two isoforms of G9a within the mouse: the brief type (GenBank accession number NP_671493 ) corresponds to human G9a and the lengthy type ( NP_665829 ), which lacks intron one, has further Arg-Gly repeats on the amino terminus.

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